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MYP_130071
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Basic Information
Kunitzin-RE
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
17 amino acids
C87H144N24O19S2
Standard
Sequence
AAKIILNPKFRCKAAFC
Physicochemical Analysis
1894.35 Da
9.85
3.77
3.55
0.2219
0.55
0.32
0.09
14.05
92.35
0.1176
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
703.18
-4.25
26.0
25.0
62.0
132.0
3.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0132333 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli K99
32 μM
MIC
PMID30958004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30958004/
RECORD: Rec_0147617 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
human red blood cells [10% hemolysis at 32 microM]
32 μM
Hemolysis
PMID30958004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30958004/
RECORD: Rec_0159943 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
A change of the last K to F reduced activity
160 μM
MIC
PaperKunitzins: Prototypes of a new class of protease inhibitor from the skin secretions of European and Asian frogs
RECORD: Rec_0172971 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli 25922
32 μM
MIC
PMID30958004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30958004/
RECORD: Rec_0179266 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
S. pullorum 7913
128 μM
MBC
PMID30958004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30958004/
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