Peptide Database

Peptide NameCrotamine Ile-19

Function Ontology

Antimicrobial

Membrane / Ion-channel modulation ▸ Ion channel modulation

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length42 amino acids

Chemical FormulaC214H332N64O54S7

DescriptionStandard

        YKQCHKKGGHCFPKEKICIPPSSDFGKMDCRWRWKCCKKGSG
    

Molecular Weight4889.78 Da

Isoelectric Point (pI)9.51

Net Charge (pH 7.0)7.87

Net Charge (pH 7.4) 7.46

Charge Density (pH 7.0) 0.1874

GRAVY Index-1.08

Hydrophobic Moment 0.46

Boman Index-0.27

Instability Index72.75

Aliphatic Index 18.57

Aromaticity 0.1190

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1912.88

LogP -18.07

H-bond Donors 73.0

H-bond Acceptors 71.0

Rotatable Bonds 164.0

Heavy Atoms 339.0

Ring Count 12.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0360930 VERIFIED: YES

Provenance & Taxonomy

OrganismCrotalus durissus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

-

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)

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