Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length440 amino acids

Chemical FormulaC2232H3496N588O619S9

DescriptionStandard

        TNPGFVVRITQAGLDYAHQHGITVLEKELAQVKLPDISGDFRIRHVGKVHYEISRLDLRSFNLPYSRISLVPNVGLQVSISNAFTELDGNWRIKLYFIRDHGSFDLKVENVYIKIDLKLGSDAAGKPTVDTSDCSTRISKVRVHFSGKFGWLYNLFHSAVESRFRKILESKVCEMVARSVRSNLQPYIQTLPVTARIDAMAGIDYSLVAPPTATAQSLDVDLKGEFFSLAHRSAVPFPPLALAFPPDHDRMVYFGASSYFFNTASFTYHAAGALVFEITDSTIPKGIDFHLNTTIFSAFIPQLEKMYPDMPMKLRLSTPSAPFLNIGPAGLSLKPVVDIQAYAILPNSSLAPLFLLSLTSNVSAVVDVKSGHIVGSLNVGRYTLFLPPLSAPQVRTLQSIMNIFASSILLPRLNARLEQGFPLPLPDRITLSNILVRFHQ
    

Molecular Weight48759.79 Da

Isoelectric Point (pI)9.24

Net Charge (pH 7.0)7.54

Net Charge (pH 7.4) 6.58

Charge Density (pH 7.0) 0.0171

GRAVY Index0.13

Hydrophobic Moment 0.79

Boman Index0.13

Instability Index35.86

Aliphatic Index 102.59

Aromaticity 0.1000

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 31985.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0377929 VERIFIED: NO

Provenance & Taxonomy

OrganismHerpetotheres cachinnans (Laughing falcon) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria