Peptide Database

Peptide NamePyocin large subunit

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length572 amino acids

Chemical FormulaC2741H4334N800O834S23

DescriptionStandard

        MGYRPDIHGKGKALSCDKTTTGARLLPSIFLDQYNVHGFCVIRLGDKTTSCPKCGKPGTVVEGDSRWMVHGVPVAVDRGIVRCDCPSGSNRIIAPLGQWMGAGPSPGQIAAEKQAAFLAQRKAEREAEEKRLAEARERNRVFAKSCLRGDGCNDAGDEREPQSNFAEMCFFRAAPAEDPATDADVPQHAQTAKKKKPTAPEDIPKPKKRGALYRWWNGNHEEMAYQAAVATAAAATRAQAATAGASVLEQLTGRALTYGTWAVRGAASLGEVAAAGAGAPVAGLLLGMMPGRLNDGEQDFIDRMRAEQLREVPTRVRYTWEKDSQGNPVPHGWHTPPGRDRVRVRKMEWDSRYQAYSFTTEEEPRITIIWTPDDSGVNTPSNTGNQARPVLPNPVIVDPLPDNTGITATTTPAPEEKSFADYILILPMPDIPPIYIYLSKPPVEFLEVELYSDFKRRSRQGKYEADHMPSAAAVKGYIKANYPGMTPEDIELASQDVAAIVIPKEVHQKISETYGGRNTPAQIDLDSRNLRAALDRNLDAIKPALKEHGATESKIEAARAKMHELNSKMGLY
    

Molecular Weight62576.09 Da

Isoelectric Point (pI)7.58

Net Charge (pH 7.0)1.47

Net Charge (pH 7.4) 0.40

Charge Density (pH 7.0) 0.0026

GRAVY Index-0.55

Hydrophobic Moment 0.63

Boman Index-0.07

Instability Index41.29

Aliphatic Index 69.90

Aromaticity 0.0664

Extinction Coeff. Reduced 74830.00

Extinction Coeff. Oxidized 75330.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0010715 VERIFIED: YES

Provenance & Taxonomy

OrganismSerratia plymuthica [Bacterium]

FamilyPyocin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Antibiotic Bacteriocin Non-hemolytic Non-ribosomal

TargetEscherichia coli (Gram-negative)