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MYP_129928
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antiviral
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
37 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
IEEISKKIEEISKKIEEISKKIEEISKKIEEISKKXK
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0036071 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical or chemical modification [Modified]
Acetylation
Amidation
N-terminal acetylation; C-terminal amidation; β-alanine at X36; palmitoylated Lys (C16 lipid) at C-terminus
Bio-Activity Profile
Antiviral
Human Influenza A Virus H3N2
6.38±1.06 μM
EC50 (influenza virus inhibition in MDCK cells)
PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0069116 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical or chemical modification [Modified]
Acetylation
Amidation
N-terminal acetylation; C-terminal amidation; β-alanine at X36; palmitoylated Lys (C16 lipid) at C-terminus
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
MERS-CoV; influenza A H1N1; influenza A H3N2; Huh-7 cells; MDCK cells
virus fusion/inhibition assays; CC50 cytotoxicity assays
PaperDe Novo Design of alpha-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. doi: 10.1021/acs.jmedchem.8b00890. PMID: 30192544. PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0205252 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical or chemical modification [Modified]
Acetylation
Amidation
N-terminal acetylation; C-terminal amidation; β-alanine at X36; palmitoylated Lys (C16 lipid) at C-terminus
Bio-Activity Profile
Antiviral
Human Influenza A Virus H1N1
1.96±0.28 μM
EC50 (influenza virus inhibition in MDCK cells)
PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0234022 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical or chemical modification [Modified]
Acetylation
Amidation
N-terminal acetylation; C-terminal amidation; β-alanine at X36; palmitoylated Lys (C16 lipid) at C-terminus
Bio-Activity Profile
Antiviral
MERS-CoV cell-cell fusion system
0.10±0.02 μM
EC50 (cell-cell fusion inhibition)
PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0249342 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical or chemical modification [Modified]
Acetylation
Amidation
N-terminal acetylation; C-terminal amidation; β-alanine at X36; palmitoylated Lys (C16 lipid) at C-terminus
Bio-Activity Profile
Hemolytic Cytotoxic
Madin-Darby canine kidney (MDCK) cells
>100 μM
CC50 / cytotoxicity assay
PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
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