‹ ›
MYP_129921
← PREVIOUS NEXT → BACK
Basic Information
Glutathione
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Glutamate carboxypeptidase II inhibition ▸ Glutamate carboxypeptidase II inhibitor
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Standard
3 amino acids
C10H17N3O6S
Standard
Sequence
ECG
Physicochemical Analysis
307.32 Da
4.05
-1.17
-1.36
-0.3910
-0.47
0.42
0.01
153.13
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
158.82
-2.21
6.0
6.0
9.0
20.0
0.0
2.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0081158 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Glutathione
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Gamma-glutamyl isopeptide linkage
Bio-Activity Profile
Antioxidant
Human plasma sample in vivo
Kinetic assay
1.6 min
PaperThe level and half-life of glutathione in human plasma
RECORD: Rec_0108675 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 0.0%, C 100.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Drug Delivery Vehicle Blood-Brain Barrier
PaperBrainpeps: the blood-brain barrier peptide database PMID22205159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22205159/
RECORD: Rec_0193400 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Glutamate Carboxypeptidase Ii Inhibitor
Glutamate carboxypeptidase II
PaperRobinson M. B., Blakely R. D., Couto R., Coyle J. T.. Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. J. Biol. Chem., 262, 14498-14506, 1987. PMID3667587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3667587/
RECORD: Rec_0277654 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
PaperTorres P., Galleguillos P., Lissi E., L¨®pez-Alarc¨®n C.. Antioxidant capacity of human blood plasma and human urine: simultaneous evaluation of the ORAC index and ascorbic acid concentration employing pyrogallol red as probe. Bioorg. Med. Chem., 16, 9171-9175, 2008.
RECORD: Rec_0380174 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Gamma peptide linkage between the carboxyl group of the glutamate side-chain and the amine group of cysteine
Bio-Activity Profile
-
Kinetic assay
Human blood plasma sample, in vivo; 96 s
PMID7439398 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7439398/