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MYP_129901
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Basic Information
HaNP-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
33 amino acids
C166H271N63O42S6
Standard
Sequence
VTCFCRRRGCASRERHIGYCRFGNTIYRLCCRR
Physicochemical Analysis
4013.71 Da
10.20
7.76
7.41
0.2352
-0.52
0.76
-0.41
68.77
47.27
0.1212
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1761.84
-20.59
75.0
57.0
132.0
277.0
5.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0225093 VERIFIED: YES
Provenance & Taxonomy
Golden hamster or [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
It contains three disulfide bonds: 3,31; 5,20; 10,30
Bio-Activity Profile
Antimicrobial Antifungal
Pseudomonas aeruginosa
46.2 μg/mL
IC50
PaperIsolation, antimicrobial activities, and primary structures of hamster neutrophil defensins.
RECORD: Rec_0242583 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31; 5-20; 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
PaperPubMed PMID: 8890190 PMID8890190 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8890190/
RECORD: Rec_0252066 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
PMID8890190 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8890190/
RECORD: Rec_0254441 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31; 5-20; 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Klebsiella oxytoca
PaperPubMed PMID: 8890190 PMID8890190 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8890190/
RECORD: Rec_0259745 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 54.5%, T 18.2%, C 27.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal Anti-Gram-positive
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
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