‹ ›
MYP_129901
← PREVIOUS NEXT → BACK
Basic Information
HaNP-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
33 amino acids
C166H271N63O42S6
Standard
Sequence
VTCFCRRRGCASRERHIGYCRFGNTIYRLCCRR
Physicochemical Analysis
4013.71 Da
10.20
7.76
7.41
0.2352
-0.52
0.76
-0.41
68.77
47.27
0.1212
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1761.84
-20.59
75.0
57.0
132.0
277.0
5.0
33.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0156568 VERIFIED: YES
Provenance & Taxonomy
Golden hamster or [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
It contains three disulfide bonds: 3,31; 5,20; 10,30
Bio-Activity Profile
Antimicrobial Antifungal
K. oxytoca
4.3 μg/mL
IC50
PaperIsolation, antimicrobial activities, and primary structures of hamster neutrophil defensins.
RECORD: Rec_0166461 VERIFIED: NO
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
PaperPatent US 2008/0269122 A1 Evidence URLhttps://patents.google.com/patent/US20080269122A1/en PatentUS 2008/0269122 A1
RECORD: Rec_0184746 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
PMID8890190 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8890190/
RECORD: Rec_0185218 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31; 5-20; 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
PaperPubMed PMID: 8890190 PMID8890190 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8890190/
RECORD: Rec_0190287 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
FIRST PREV 1 2 3 4 5 6 7 NEXT LAST
Showing 5 records on this page · Page 4 of 7