Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length488 amino acids

Chemical FormulaC2424H3980N668O663S25

DescriptionStandard

        MSLFSWIIVVLLIATTSGVNPGVKVRLTAKGLEYGKVQVGMAAIQQNLRTIKIPDISGKKRISRIGKVKYRLSNMRILNVELPKSAVDPVPGTGVRLAMSNAKISMRGNWRVKFFRIMKSGSFDLNVDRLGVSANIAIKSDSTGRPVVSTPSCSASVGSVRVKFRGGASWLYNLFNKFINKALRKAMQKQKNNIHQICLVVSLMLILAKVDKLAEIDYSMTSSPTISKSSIDLNMKGEFYNIGRHQEPPFSPAAFSLPPQVNKMAYIGMSAFTANSAGFVYNRAGILTLNITDDMIPKSSPIRLNTRALGTFIPEIARRFPGLLVKMVVKTAKPPVITFQPNNATVQTIGTITAFAIQRNTTLSPLFVLNIVGPHSSEMNINVILPHLHRLDLTMGTSSVGQFQVRALDNILEIVLRAVIIPLVNVKLSGGYPLPATGKMKLMNTDLQILKVRDDILCITRYMCWIYYITGILMRPEQSTQNIIVRMK
    

Molecular Weight53891.23 Da

Isoelectric Point (pI)10.44

Net Charge (pH 7.0)37.89

Net Charge (pH 7.4) 37.28

Charge Density (pH 7.0) 0.0777

GRAVY Index0.15

Hydrophobic Moment 0.83

Boman Index0.10

Instability Index43.51

Aliphatic Index 105.84

Aromaticity 0.0676

Extinction Coeff. Reduced 38390.00

Extinction Coeff. Oxidized 38640.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0421063 VERIFIED: NO

Provenance & Taxonomy

OrganismEcheneis naucrates [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria