Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2414H3837N625O674S14

DescriptionStandard

        MAREPDSALRWAGLLVLSTLSTAVIATTNPGVMARITQKGLDYACQQGVAVLQKELEKIKIPEFSGSFKVKHLGKGHYRFYSMVIRGFQLPSSHIKLVPEKGLDLSISNANIKISGKWKARKKFIKTSGNFDLSVEGISISAGLQLGFDPSSGLPTATCSSCSNQINAVHVHISGSKLGWLIQLFHKKIESSIRKTMESKICQVVTSSVSSKLQSYLKTLRVTTKIDKVAGINYSLVAPPTITADNLDGQLKGEFFNVAHPSPPPFTPPVLAFPADHNRMVYLGLSDYFFNTAGFVYQQAGALHLTITDNMIPKGSKFRLTTTFFGVLIPQVAKMFPNMTMQLNIGAPSPPYLTVLPTGLVFTPILETQAFAVLPNSSLAPLFELQLSTNFSVEVGTTPDRLIGKLRLNRLLLELKHSDVGPFSVTELQAVMNYLLPTIVIPKVNERLLEGFPLPLPADIQLSNLVLQTHQNFLLFGADVHYG
    

Molecular Weight52847.98 Da

Isoelectric Point (pI)9.49

Net Charge (pH 7.0)14.53

Net Charge (pH 7.4) 13.55

Charge Density (pH 7.0) 0.0301

GRAVY Index0.12

Hydrophobic Moment 0.76

Boman Index0.15

Instability Index35.81

Aliphatic Index 101.51

Aromaticity 0.0849

Extinction Coeff. Reduced 32890.00

Extinction Coeff. Oxidized 33140.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0033060 VERIFIED: NO

Provenance & Taxonomy

OrganismMustela putorius furo [Animal]

FamilyBPI/LBP

Tax ID9669

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence