Peptide Database

Peptide NamegB122(637-650)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC87H112N22O19

DescriptionStandard

        HRRYFTFGGGYVYF
    

Molecular Weight1769.96 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)1.84

Net Charge (pH 7.4) 1.59

Charge Density (pH 7.0) 0.1317

GRAVY Index-0.39

Hydrophobic Moment 0.43

Boman Index0.10

Instability Index59.81

Aliphatic Index 20.71

Aromaticity 0.4286

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 675.02

LogP -3.30

H-bond Donors 26.0

H-bond Acceptors 22.0

Rotatable Bonds 51.0

Heavy Atoms 128.0

Ring Count 7.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0061071 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

RECORD: Rec_0282822 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HSV Entry inhibition

TargetHerpes simplex virus type 1 (HSV-1)

Activity31.2±5.1 μM

MethodEC50

Half-LifeMammalian: 3.5 h; Yeast: 10 min; E. coli: >10 h

PaperMultiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection. | Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR. | Antimicrob Agents Chemother. 2009 Mar;53(3):987-96. | DOI:10.1128/AAC.00793-08 | PMID:19104014 PMID19104014 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19104014/

RECORD: Rec_0368724 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHerpes simplex virus type 1(HSV-1):comprehensive antiviral activity

Activity31.2±5.1 μM

MethodEC50