Peptide Database

Peptide NameS12

Function Ontology

Immunology ▸ Cytokine / receptor signaling modulation ▸ TLR inhibition

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC165H277N61O38S2

DescriptionStandard

        EMFTILEEYFMYRGLLGLRRRRRRRRRR
    

Molecular Weight3787.48 Da

Isoelectric Point (pI)11.92

Net Charge (pH 7.0)7.84

Net Charge (pH 7.4) 7.66

Charge Density (pH 7.0) 0.2800

GRAVY Index-1.25

Hydrophobic Moment 0.57

Boman Index-0.69

Instability Index218.54

Aliphatic Index 69.64

Aromaticity 0.1429

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1702.51

LogP -13.26

H-bond Donors 68.0

H-bond Acceptors 48.0

Rotatable Bonds 133.0

Heavy Atoms 266.0

Ring Count 4.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0089039 VERIFIED: YES

Provenance & Taxonomy

OrganismOrthopoxvirus vaccinia [Virus]

FamilyP13/A52R-derived

Tax ID10245.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory Anti-inflammatory TLR inhibitor

TargetCpG- or LPS-stimulated RAW264.7 macrophage assays