Peptide Database

Peptide NameThrombin

Function Ontology

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length625 amino acids

Chemical FormulaC3090H4810N892O939S32

DescriptionStandard

        MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS
    

Molecular Weight70504.74 Da

Isoelectric Point (pI)5.97

Net Charge (pH 7.0)-7.56

Net Charge (pH 7.4) -8.94

Charge Density (pH 7.0) -0.0121

GRAVY Index-0.58

Hydrophobic Moment 0.81

Boman Index-0.10

Instability Index41.08

Aliphatic Index 70.37

Aromaticity 0.0880

Extinction Coeff. Reduced 105310.00

Extinction Coeff. Oxidized 106810.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0328649 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Bos taurus [Animal]

FamilyCoagulation factor

Tax ID9606;9913

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Coagulation factor replacement

Half-LifeUnfortunately, little has been reported about the systemic pharmacokinetics of bovine thrombin preparations [T155].

RECORD: Rec_0426708 VERIFIED: NO