Peptide Database

Peptide NameFluA-PB1(1-10)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC54H87N11O15S

DescriptionStandard

        MDVNPTLLFL
    

Molecular Weight1162.40 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.50

Net Charge (pH 7.4) -1.71

Charge Density (pH 7.0) -0.1499

GRAVY Index1.10

Hydrophobic Moment 0.11

Boman Index0.45

Instability Index6.12

Aliphatic Index 146.00

Aromaticity 0.1000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 417.05

LogP -1.21

H-bond Donors 13.0

H-bond Acceptors 15.0

Rotatable Bonds 35.0

Heavy Atoms 81.0

Ring Count 2.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0060681 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

RECORD: Rec_0065288 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 50.0%, E 0.0%, T 0.0%, C 50.0% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Antimicrobial

RECORD: Rec_0125336 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetInfluenza A(FluA):inhibition of PA-binding activity and virus replication

Activity3 μM

MethodIC50

RECORD: Rec_0218966 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Replication inhibition

TargetInfluenza A (FluA)

Activity3 μM

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperIdentification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication. | Wunderlich K, Mayer D, Ranadheera C, Holler AS, Mänz B, Martin A, Chase G, Tegge W, Frank R, Kessler U, Schwemmle M. | PLoS One. 2009 Oct 20;4(10):e7517. | DOI:10.1371/journal.pone.0007517 | PMID:19841738 PMID19841738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19841738/

RECORD: Rec_0331465 VERIFIED: YES

Provenance & Taxonomy

OrganismInfluenza A virus [Virus]

FamilyVirus-derived peptide

Tax ID11320;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Replication inhibitor

TargetInfluenza A virus (Replication); MDCK

Activity3 μM

MethodELISA

PaperIdentification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication. | Wunderlich K, Mayer D, Ranadheera C, Holler AS, Manz B, Martin A, Chase G, Tegge W, Frank R, Kessler U, Schwemmle M. | PLoS One. 2009 | PMID:19841738 PMID19841738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19841738/