Peptide Database

Peptide NameCertolizumab pegol

Function Ontology

Immunology ▸ Cytokine / receptor signaling modulation ▸ TNF-alpha inhibition

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Standard StatusStandard

Sequence Length228 amino acids

Chemical FormulaC1097H1700N288O355S6

DescriptionStandard

        DIQMTQSPSSLSASVGDRVTITCKASQNVGTNVAWYQQKPGKAPKALIYSASFLYSGVPYRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNIYPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECEVQLVESGGGLVQP
    

Molecular Weight24795.34 Da

Isoelectric Point (pI)6.17

Net Charge (pH 7.0)-1.10

Net Charge (pH 7.4) -1.54

Charge Density (pH 7.0) -0.0048

GRAVY Index-0.37

Hydrophobic Moment 0.58

Boman Index0.02

Instability Index47.51

Aliphatic Index 69.65

Aromaticity 0.1009

Extinction Coeff. Reduced 28880.00

Extinction Coeff. Oxidized 29130.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0318868 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyPEGylated Fab fragment

Tax ID9606

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitynoncanonical stereochemical or chemical modification [Modified]

Other ModsPEGylation

Bio-Activity Profile

Function

Immunomodulatory Anti-inflammatory TNF inhibitor

Half-LifeElimination half life- 14 d