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MYP_129722
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Basic Information
Combi-2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
6 amino acids
C49H62N16O7
Standard
Sequence
FRWWHR
Physicochemical Analysis
987.12 Da
12.00
1.85
1.59
0.3079
-1.87
1.02
-0.44
143.27
0.00
0.5000
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
392.88
0.01
16.0
10.0
27.0
72.0
6.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007265 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
18 μg/mL
IC50
PaperNovel antimicrobial compounds identified using synthetic combinatorial library technology.
RECORD: Rec_0058178 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Designed peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0070306 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
100 μM
MIC
PMID28105725 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28105725/
RECORD: Rec_0092025 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
PMID15853943 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15853943/
RECORD: Rec_0111201 VERIFIED: YES
Provenance & Taxonomy
porcine cathelicidin peptide [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Jurkat
65 μM
IC50
PaperSelective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. Biochim Biophys Acta Biomembr. 2020 Aug 1;1862(8):183228. doi: 10.1016/j.bbamem.2020.183228. PMID: 32126228. PMID32126228 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32126228/
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