Peptide Database

Peptide NameRTD-3 (rhesus theta defensin 3)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC84H140N30O21S6

DescriptionStandard

        GFCRCICTRGFCRCICTR
    

Molecular Weight2098.59 Da

Isoelectric Point (pI)9.01

Net Charge (pH 7.0)3.70

Net Charge (pH 7.4) 3.41

Charge Density (pH 7.0) 0.2056

GRAVY Index0.52

Hydrophobic Moment 0.64

Boman Index-0.13

Instability Index40.95

Aliphatic Index 43.33

Aromaticity 0.1111

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 846.08

LogP -10.13

H-bond Donors 39.0

H-bond Acceptors 31.0

Rotatable Bonds 67.0

Heavy Atoms 141.0

Ring Count 2.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0415906 VERIFIED: YES

Provenance & Taxonomy

OrganismMacaca mulatta [Animal]

FamilyDefensin

Tax ID9544

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermCyclization

C-TermCyclization

Disulfide3-16, 5-14, 7-12

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1 C:inhibition of infection in JC53-BL cells

Activity4.31±0.9 μg/mL

MethodIC50

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