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MYP_129706
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Basic Information
RTD-3 (rhesus theta defensin 3)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
18 amino acids
C84H140N30O21S6
Standard
Sequence
GFCRCICTRGFCRCICTR
Physicochemical Analysis
2098.59 Da
9.01
3.70
3.41
0.2056
0.52
0.64
-0.13
40.95
43.33
0.1111
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
846.08
-10.13
39.0
31.0
67.0
141.0
2.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0033407 VERIFIED: YES
Provenance & Taxonomy
Macaca mulatta [Animal]
Defensin
9544
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
3-16, 5-14, 7-12
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 D:inhibition of infection in JC53-BL cells
2.31±0.21 μg/mL
IC50
PaperPubMed PMID: 15210812 PMID15210812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15210812/
RECORD: Rec_0042624 VERIFIED: YES
Provenance & Taxonomy
Macaca mulatta [Animal]
Defensin
9544
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
3-16, 5-14, 7-12
Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 D | JC53-BL cells
2.31±0.21 μg/mL
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRetrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1 | Wang W, Owen SM, Rudolph DL, Cole AM, Hong T, Waring AJ, Lal RB, Lehrer RI. | J Immunol. 2004 Jul 1;173(1):515-20. | DOI:10.4049/jimmunol.173.1.515 | PMID:15210812 PMID15210812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15210812/
RECORD: Rec_0048945 VERIFIED: YES
Provenance & Taxonomy
Macaca mulatta [Animal]
Defensin
9544
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Anti-Gram-positive Anti-Gram-negative
HIV
PMID11675394 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11675394/
RECORD: Rec_0049856 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0078453 VERIFIED: YES
Provenance & Taxonomy
Macaca mulatta [Animal]
Defensin
9544
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
3-16, 5-14, 7-12
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 BF:inhibition of infection in JC53-BL cells
0.89 μg/mL
IC50
PaperPubMed PMID: 15210812 PMID15210812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15210812/
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