Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length492 amino acids

Chemical FormulaC2459H3857N629O684S19

DescriptionStandard

        MLWVLVMLLGIRTEALAPGIKAEITLKGLDYGKEVGMEFLNSALLKLSIPDLKGSYSIPLVGPVEWAMTGFQVKALNLGESLIAFVPNSGLKLSMGPAEAEVDGHWSVVASLIRDSGTLSLNVRDVTLAVQVGVHWNGAGRLVVSSEGCSSHIGRLEVTFHGGASWLYNIFFEVLEDLIRKQLNSKLCESIGNAVQTLERTLQTIPESRHISPLADLNCSLVAAPLIMEQSIELDFKGEFYSPASHKEFPVPPAPFSLWKQNDHMLLLGVSDFVANSAAFVYYQAGALSRTFNDSQIPKWFPIRLNTKNFKNFVPELQKRFPNTTMALKIFARLPPRLQSQSGALKVVLPGALQAFVLPKGNSAVPVFLLDMDTEASGQVFASGKNIGASLKLTKAFWPLPQMSIMEPEPGLLPALEELSSQWPQLVLGPYLLWLCLALSFFCTCLIPIEASFQGWREARSWGPQALLGNMASLTDQLLLLGINAKPNCHSS
    

Molecular Weight53784.97 Da

Isoelectric Point (pI)6.27

Net Charge (pH 7.0)-2.81

Net Charge (pH 7.4) -3.63

Charge Density (pH 7.0) -0.0057

GRAVY Index0.21

Hydrophobic Moment 0.77

Boman Index0.19

Instability Index41.66

Aliphatic Index 104.67

Aromaticity 0.0894

Extinction Coeff. Reduced 76430.00

Extinction Coeff. Oxidized 76805.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0034691 VERIFIED: NO

Provenance & Taxonomy

OrganismMonodelphis domestica [Animal]

FamilyBPI

Tax ID13616

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence