Peptide Database

Peptide NameAscaphin-8-3

Function Ontology

Anticancer

Anticancer ▸ Antitumor

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC96H161N23O24

DescriptionStandard

        GFKDLLKGAAKSLVKSVLF
    

Molecular Weight2021.44 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.1451

GRAVY Index0.59

Hydrophobic Moment 0.66

Boman Index0.20

Instability Index-13.36

Aliphatic Index 123.16

Aromaticity 0.1053

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 768.96

LogP -4.62

H-bond Donors 27.0

H-bond Acceptors 27.0

Rotatable Bonds 71.0

Heavy Atoms 143.0

Ring Count 2.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0049846 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Anticancer Antitumor

TargetHEK293T

Activity16.35 μM

MethodIC50

RECORD: Rec_0138041 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Anticancer Antitumor

TargetC4-2B

Activity7.17 μM

MethodIC50

RECORD: Rec_0164620 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Hemolytic

Targetrabbit RBCs

Activity40.61 μM

MethodHC50

RECORD: Rec_0423908 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Anticancer Antitumor

TargetA549

Activity2.39 μM

MethodIC50