Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length187 amino acids

Chemical FormulaC924H1434N234O266S6

DescriptionStandard

        MLPSVMVVFAILSCTRAENPAVQVTLTDKWLQYVKHVGAGWIQDKLEHITFPDISGDVDILIGHVYYTLSGIRITKCDLPEPVLEFFQSTGLKTSIVGLNAALVGNWRTSFGIIHDGGSFDMAIFSVSLTSVVQLGRDPDGHLSITSIGCEPQVGNVAIQFHGGASFIFQPFVDDFKGKIVSVIQSS
    

Molecular Weight20269.07 Da

Isoelectric Point (pI)5.35

Net Charge (pH 7.0)-5.99

Net Charge (pH 7.4) -6.58

Charge Density (pH 7.0) -0.0320

GRAVY Index0.36

Hydrophobic Moment 0.58

Boman Index0.25

Instability Index28.13

Aliphatic Index 104.65

Aromaticity 0.0963

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 21095.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7876.19

LogP -87.35

H-bond Donors 272.0

H-bond Acceptors 272.0

Rotatable Bonds 657.0

Heavy Atoms 1430.0

Ring Count 35.0

Amide Bonds 199.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0370978 VERIFIED: NO

Provenance & Taxonomy

OrganismNothobranchius rachovii [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria