Peptide Database

Peptide NameSomatrogon

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Standard StatusStandard

Sequence Length275 amino acids

Chemical FormulaC1359H2129N361O420S7

DescriptionStandard

        SSSSKAPPPSLPSPSRLPGPSDTPILPQFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGFSSSSKAPPPSLPSPSRLPGPSDTPILPQSSSSKAPPPSLPSPSRLPGPSDTPILPQ
    

Molecular Weight30469.06 Da

Isoelectric Point (pI)5.97

Net Charge (pH 7.0)-2.28

Net Charge (pH 7.4) -2.76

Charge Density (pH 7.0) -0.0083

GRAVY Index-0.50

Hydrophobic Moment 0.68

Boman Index-0.03

Instability Index69.46

Aliphatic Index 76.25

Aromaticity 0.0800

Extinction Coeff. Reduced 17420.00

Extinction Coeff. Oxidized 17670.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0130670 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Cricetulus griseus [Animal]

FamilyInsulin

Tax ID9606;10029

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsGlycosylation, Phosphorylation, Lipidation

Bio-Activity Profile

Function

Hormone replacement

TargetCHO

Half-LifeFollowing subcutaneous administration of 0.66 mg/kg/wk in pediatric patients with growth hormone deficiency, the half-life was 28.3 hours. Somatrogon was detected in the circulation for about 6 days after the last dose.[L39362]