Peptide Database

Peptide NameSLAY-screened peptide P5381

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC106H160N36O27S

DescriptionStandard

        HRRAGFTYGNASMRRLFYQA
    

Molecular Weight2402.69 Da

Isoelectric Point (pI)11.55

Net Charge (pH 7.0)3.85

Net Charge (pH 7.4) 3.59

Charge Density (pH 7.0) 0.1923

GRAVY Index-0.82

Hydrophobic Moment 0.48

Boman Index-0.25

Instability Index70.82

Aliphatic Index 34.50

Aromaticity 0.2000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1059.60

LogP -11.35

H-bond Donors 40.0

H-bond Acceptors 33.0

Rotatable Bonds 77.0

Heavy Atoms 170.0

Ring Count 5.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0229018 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/