Peptide Database

Peptide NameDermaseptin-S12 (DRS-S12)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length72 amino acids

Chemical FormulaC351H569N95O118S5

DescriptionStandard

        ASLKKSLFLVLFLGLVSLSICEEEKRENEDEENQEDDEQSEMRRGLWSKIKEAAKTAGKMAMGFVNDMVGEQ
    

Molecular Weight8168.16 Da

Isoelectric Point (pI)4.59

Net Charge (pH 7.0)-6.18

Net Charge (pH 7.4) -6.42

Charge Density (pH 7.0) -0.0859

GRAVY Index-0.59

Hydrophobic Moment 0.64

Boman Index-0.12

Instability Index57.39

Aliphatic Index 77.22

Aromaticity 0.0556

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3510.00

LogP -34.72

H-bond Donors 120.0

H-bond Acceptors 117.0

Rotatable Bonds 294.0

Heavy Atoms 569.0

Ring Count 5.0

Amide Bonds 77.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0058098 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa sauvagei [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetGram-negative and Gram-positive bacteria