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MYP_129501
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Lipid metabolism ▸ Cholesterol-lowering
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Bone metabolism ▸ Osteoanabolic activity
Standard
3 amino acids
C15H25N3O4
Standard
Sequence
VPP
Physicochemical Analysis
311.38 Da
5.50
-0.27
-0.48
-0.0887
0.33
0.32
0.44
135.07
96.67
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
103.94
0.04
2.0
4.0
4.0
22.0
2.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0148053 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Osteoanabolic Bone-protective Bone-promoting
Ovariectomized rats
PaperEffects of Bioactive Peptide, Valyl-Prolyl-Proline (VPP), and Lactobacillus helveticus Fermented Milk Containing VPP on Bone Loss in Ovariectomized Rats | Narva, M. et al. | DOI: 10.1159/000100823 PMID17356257 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17356257/
RECORD: Rec_0151467 VERIFIED: YES
Provenance & Taxonomy
Triticum aestivum [Plant]
Bioactive peptides
4565
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme
9 μM
IC50
PaperBioactive peptides in amaranth (Amaranthus hypochondriacus) seed | PubMed PMID 21985248 PMID21985248;18211015;21985240 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21985248/
RECORD: Rec_0156160 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]; Skimmed milk [Plant]; Viridiplantae [Plant]; Poaceae [Plant]; Lactobacillus helveticus [Bacterium]; Gallus gallus [Animal]; Insecta [Animal]; Bacteria [Bacterium]
9913; 33090; 33090; 4479; 1587; 9031; 50557; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperEvaluation of the allergenicity of goat milk, cow milk, and their lactosera in a guinea pig model PMID19233776 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19233776/
RECORD: Rec_0157332 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rats (SHR)
9 μM
IC50
PaperAnti-hypertensive activity of fermented dairy products containing biogenic peptides PMID12369200 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12369200/
RECORD: Rec_0162762 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
9 μM
IC50
PaperIdentification of antioxidant and ACE-inhibitory peptides in fermented Milk
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