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MYP_129425
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Basic Information
Toxin LyeTx 1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
25 amino acids
C135H226N36O30
Standard
Sequence
IWLTALKFLGKNLGKHLAKQQLAKL
Physicochemical Analysis
2833.46 Da
10.60
4.84
4.58
0.1937
0.15
0.63
0.13
18.11
136.80
0.0800
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1085.79
-4.91
37.0
36.0
100.0
201.0
4.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0308271 VERIFIED: YES
Provenance & Taxonomy
Lycosa erythrognatha [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID19946788 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19946788/
RECORD: Rec_0326356 VERIFIED: YES
Provenance & Taxonomy
Lycosa erythrognatha [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
rabbit erythrocytes
PMID19946788 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19946788/
RECORD: Rec_0326916 VERIFIED: YES
Provenance & Taxonomy
Lycosa erythrognatha [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
[Refer PubMed ID - 34169094: Acinetobacter baumannii [9] (
2.80
MIC
PMID19946788 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19946788/
RECORD: Rec_0344896 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0347993 VERIFIED: YES
Provenance & Taxonomy
Lycosa erythrognatha [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
7.81 μM
MIC
PMID19946788 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19946788/
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