Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length187 amino acids

Chemical FormulaC938H1485N259O249S8

DescriptionStandard

        PTALPTAQEPMLLLAVTEFVANSAAFTYFTAGVLRKNISSDMLPRRFPLQLRTKSMGVFSPQLQQRYPDHPMELHLSARQQPLLSCHPDALHGAFFGSAEAFVVLPNATRVPAFLLNIDANVTGKPTITRNRLGGTVSLKDPLCLPRARLRGLPVPQVKRLETLLKFGLWLFGVPWANSECCPHPVP
    

Molecular Weight20630.93 Da

Isoelectric Point (pI)9.87

Net Charge (pH 7.0)8.37

Net Charge (pH 7.4) 7.97

Charge Density (pH 7.0) 0.0448

GRAVY Index0.03

Hydrophobic Moment 0.57

Boman Index0.09

Instability Index55.06

Aliphatic Index 93.90

Aromaticity 0.0802

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7964.10

LogP -91.96

H-bond Donors 274.0

H-bond Acceptors 270.0

Rotatable Bonds 648.0

Heavy Atoms 1454.0

Ring Count 43.0

Amide Bonds 201.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0279354 VERIFIED: NO

Provenance & Taxonomy

OrganismHaliaeetus albicilla (White-tailed sea-eagle) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria