Peptide Database

Peptide NameL10, 11-DPS3 (Derived from dermaseptin-PS3 (DPS3))

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length23 amino acids

Chemical FormulaC122H206N32O33

DescriptionStandard

        ALWKDILKNLLKAALNEINQIVQ
    

Molecular Weight2649.14 Da

Isoelectric Point (pI)8.54

Net Charge (pH 7.0)0.80

Net Charge (pH 7.4) 0.60

Charge Density (pH 7.0) 0.0346

GRAVY Index0.22

Hydrophobic Moment 0.72

Boman Index0.13

Instability Index22.26

Aliphatic Index 161.30

Aromaticity 0.0435

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1087.42

LogP -6.24

H-bond Donors 35.0

H-bond Acceptors 34.0

Rotatable Bonds 93.0

Heavy Atoms 187.0

Ring Count 2.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0389943 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus NCTC 10788

Activity8 μM

MethodMIC

FIRST PREV 1 2 3

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