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MYP_129275
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Basic Information
Pelophylaxin-3
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiviral
Standard
33 amino acids
C144H257N39O45S3
Standard
Sequence
GLMDSLKGLAATAGKTVLQGLLKTASCKLEKTC
Physicochemical Analysis
3351.01 Da
9.24
2.74
2.50
0.0830
0.27
0.52
0.11
22.43
103.64
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1363.69
-15.13
50.0
51.0
119.0
231.0
0.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0004219 VERIFIED: YES
Provenance & Taxonomy
Pelophylax fukienensis [Animal]
Pelophylaxin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial
PaperT. Chen et al. / Genomics 87 (2006) 638-644. Cloning from tissue surrogates: Antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs Evidence URLhttps://www.uniprot.org/uniprotkb/Q2WCN6/entry
RECORD: Rec_0009897 VERIFIED: YES
Provenance & Taxonomy
Fukien gold-striped pond [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
S. sonnei
100 μg/mL
MIC
PaperPelophylaxins: novel antimicrobial peptide homologs from the skin secretion of the Fukien gold-striped pond frog, Pelophylax plancyi fukienensis: identification by "shotgun" cDNA cloning and sequence analysis.
RECORD: Rec_0029575 VERIFIED: YES
Provenance & Taxonomy
Fukien gold-striped pond [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
A.hydrophila
>100 μg/mL
MIC
PaperPelophylaxins: novel antimicrobial peptide homologs from the skin secretion of the Fukien gold-striped pond frog, Pelophylax plancyi fukienensis: identification by "shotgun" cDNA cloning and sequence analysis.
RECORD: Rec_0042439 VERIFIED: YES
Provenance & Taxonomy
Rana amurensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0052315 VERIFIED: YES
Provenance & Taxonomy
Fukien gold-striped pond [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
S. iniae
100 μg/mL
MIC
PaperPelophylaxins: novel antimicrobial peptide homologs from the skin secretion of the Fukien gold-striped pond frog, Pelophylax plancyi fukienensis: identification by "shotgun" cDNA cloning and sequence analysis.
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