Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length126 amino acids

Chemical FormulaC640H993N157O181S6

DescriptionStandard

        MCTKTIPVLWGCFLLWNLYVSSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLLG
    

Molecular Weight13975.06 Da

Isoelectric Point (pI)8.56

Net Charge (pH 7.0)1.57

Net Charge (pH 7.4) 1.24

Charge Density (pH 7.0) 0.0125

GRAVY Index0.10

Hydrophobic Moment 0.68

Boman Index0.18

Instability Index34.67

Aliphatic Index 92.86

Aromaticity 0.1190

Extinction Coeff. Reduced 23950.00

Extinction Coeff. Oxidized 24075.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5397.55

LogP -46.35

H-bond Donors 187.0

H-bond Acceptors 190.0

Rotatable Bonds 457.0

Heavy Atoms 984.0

Ring Count 25.0

Amide Bonds 136.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0072350 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence