Peptide Database

Peptide NameSLAY-screened peptide P5764

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC103H168N34O29S

DescriptionStandard

        TAICTFAPHSIDRNKNARLHL
    

Molecular Weight2378.71 Da

Isoelectric Point (pI)9.50

Net Charge (pH 7.0)1.56

Net Charge (pH 7.4) 1.25

Charge Density (pH 7.0) 0.0744

GRAVY Index-0.30

Hydrophobic Moment 0.46

Boman Index-0.08

Instability Index53.66

Aliphatic Index 88.57

Aromaticity 0.0476

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1027.88

LogP -11.42

H-bond Donors 37.0

H-bond Acceptors 34.0

Rotatable Bonds 76.0

Heavy Atoms 167.0

Ring Count 4.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0400235 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/