Peptide Database

Peptide NameNeutrophil antibiotic peptide NP-3A (RatNP-3a) (Neutrophil defensin 3)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length87 amino acids

Chemical FormulaC396H654N118O128S7

DescriptionStandard

        MRTLTLLTTLLLLALHTQAESPQGSTKEAPDEEQDISVFFGGDKGTALQDAAVKAGVTCSCRTSSCRFGERLSGACRLNGRIYRLCC
    

Molecular Weight9340.60 Da

Isoelectric Point (pI)7.58

Net Charge (pH 7.0)0.54

Net Charge (pH 7.4) 0.17

Charge Density (pH 7.0) 0.0062

GRAVY Index-0.09

Hydrophobic Moment 0.72

Boman Index-0.02

Instability Index38.67

Aliphatic Index 81.95

Aromaticity 0.0460

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3983.44

LogP -49.34

H-bond Donors 148.0

H-bond Acceptors 137.0

Rotatable Bonds 314.0

Heavy Atoms 649.0

Ring Count 7.0

Amide Bonds 91.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0001428 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyAlpha-defensin; Defensin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)