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MYP_129034
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Standard
14 amino acids
C68H108N14O24S2
Standard
Sequence
ILMCFSIDSPDSLE
Physicochemical Analysis
1569.79 Da
4.05
-3.24
-3.46
-0.2314
0.66
0.19
0.29
76.56
111.43
0.0714
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
605.42
-4.89
21.0
23.0
50.0
108.0
2.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037121 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 35.7%, C 64.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0054468 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-RSV Entry inhibition
Respiratory syncytial virus (RSV) | HEp-2 cells
3.5 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperAntiviral activity of RhoA-derived peptides against respiratory syncytial virus is dependent on formation of peptide dimers. | Budge PJ, Lebowitz J, Graham BS. | Antimicrob Agents Chemother. 2003 Nov;47(11):3470-7. | DOI:10.1128/AAC.47.11.3470-3477.2003 | PMID:14576104 PMID14576104 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14576104/
RECORD: Rec_0201214 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
respiratory syncytial virus(RSV):inhibition of RSV replication in HEp-2 cells
3.5 μM
IC50
PaperPubMed PMID: 14576104 PMID14576104 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14576104/
RECORD: Rec_0305280 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 14576104 PMID14576104 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14576104/
RECORD: Rec_0328706 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
RhoA-derived
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Respiratory syncytial virus (Replication); HEp-2
3.5 μM
Viral antigen reduction assay
PaperAntiviral activity of RhoA-derived peptides against respiratory syncytial virus is dependent on formation of peptide dimers. | Budge PJ, Lebowitz J, Graham BS. | Antimicrob Agents Chemother. 2003 | PMID:14576104 PMID14576104 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14576104/