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MYP_128761
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Basic Information
P6 (Derived from P5)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
9 amino acids
C74H97N27O10
Standard
Sequence
HRWWRWWRR
Physicochemical Analysis
1524.74 Da
12.00
3.85
3.59
0.4275
-2.76
1.02
-0.81
199.82
0.00
0.4444
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
635.56
-0.81
27.0
15.0
43.0
111.0
9.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009394 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human red blood cells
PaperModulating short tryptophan- and arginine-rich peptides activity by substitution with histidine. Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024. PMID: 28372989. PMID28372989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28372989/
RECORD: Rec_0024891 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
8 μM
MIC
PaperModulating short tryptophan- and arginine-rich peptides activity by substitution with histidine. Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024. PMID: 28372989. PMID28372989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28372989/
RECORD: Rec_0083568 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
PaperModulating short tryptophan- and arginine-rich peptides activity by substitution with histidine. Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024. PMID: 28372989. PMID28372989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28372989/
RECORD: Rec_0169970 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperModulating short tryptophan- and arginine-rich peptides activity by substitution with histidine. Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024. PMID: 28372989. PMID28372989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28372989/
RECORD: Rec_0212363 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
1 μg/mL
MIC
PMID28372989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28372989/
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