Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length496 amino acids

Chemical FormulaC2507H3904N638O726S16

DescriptionStandard

        MRTKTIPVVWGCFFLWNLSISSSQTTYPGIKARATQRALDYGVQAGMEMIEQMVKERNIPDINGSESLEFLKVDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISTNWEIKSPLFRDAGGADLFLSGVYFTGIVILTRNVSGHPTLKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIITGEVEALNANLSALEVLRKIDNYTLLDYSLIDSPEVTENYLDLNLKGVFYPLENLADPPFSPVPFMLPERSDSMLYIGISEYFFKSASFAYFTAGAFDVTLSTKEISNHFIQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPVISLRPGNFTLDIPASIIILTQPKNSTVETIVSMDFVASTSVGLVILGQRLICSLSLNRFRLSLPEPNHSNIEVLRFENILSSILHFGVLPLANGKESLGNAMTLIWLNGFLLISTDLNYETSSKRQPSFHGWEGLNLISRQWRGKPAP
    

Molecular Weight55110.69 Da

Isoelectric Point (pI)5.59

Net Charge (pH 7.0)-7.78

Net Charge (pH 7.4) -8.57

Charge Density (pH 7.0) -0.0157

GRAVY Index0.11

Hydrophobic Moment 0.72

Boman Index0.16

Instability Index36.34

Aliphatic Index 101.03

Aromaticity 0.1028

Extinction Coeff. Reduced 56840.00

Extinction Coeff. Oxidized 57090.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0169920 VERIFIED: NO

Provenance & Taxonomy

OrganismProlemur simus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence