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MYP_128625
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Basic Information
Protegrin-2 (Protegrin 2; PG-2; pigs, mammals, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
16 amino acids
C81H137N31O18S4
Standard
Sequence
RGGRLCYCRRRFCICV
Physicochemical Analysis
1961.41 Da
9.88
4.72
4.46
0.2950
0.04
0.35
-0.35
78.67
66.88
0.1250
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
829.55
-8.09
37.0
27.0
64.0
134.0
2.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0156776 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://patents.google.com/patent/US20050260715A1/en PatentUS 2005/0260715 A1
RECORD: Rec_0187709 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Cathelicidin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Listeria monocytogenes
25 μg/mL
MIC
PMID8335113 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8335113/
RECORD: Rec_0227676 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Protegrin
9823
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ML-35
25 μg/mL
MIC
PaperPubMed PMID: 8335113 | PubMed PMID: 8250892 PMID8335113;8250892 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8335113/
RECORD: Rec_0271097 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Protegrin
9823
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Listeria moncyrogenes strain EGD
25 μg/mL
MIC
PaperPubMed PMID: 8335113 | PubMed PMID: 8250892 PMID8335113;8250892 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8335113/
RECORD: Rec_0271485 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
cathelicidin family
9823; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
6-15; 8-13
Bio-Activity Profile
Antimicrobial cathelicidin family Antibacterial Host defense
PaperPDB 2MUH structural record; NMR; chain A; residues 1-16
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