Peptide Database

Peptide Name4318(derived from the RNase H domain of HIV-1 RT (20-mes)),65(derived from the HIV-1 HXB2 Pol region of the viral genome)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC93H151N23O34

DescriptionStandard

        LQDSGLEVNIVTDSQYALGI
    

Molecular Weight2135.33 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-3.24

Net Charge (pH 7.4) -3.44

Charge Density (pH 7.0) -0.1618

GRAVY Index0.26

Hydrophobic Moment 0.28

Boman Index0.23

Instability Index81.62

Aliphatic Index 131.50

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 938.31

LogP -10.03

H-bond Donors 31.0

H-bond Acceptors 31.0

Rotatable Bonds 71.0

Heavy Atoms 150.0

Ring Count 1.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0412906 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

Targetinhibition of strand transfer catalyzed by C130A integrase

Activity20 μM

MethodIC50

PaperPeptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase. J Biol Chem. 2005 Jun 10;280(23):21987-21996. doi: 10.1074/jbc.M414679200. PMID: 15790559 PMID15790559;16879966 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15790559/

RECORD: Rec_0421732 VERIFIED: YES