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MYP_128396
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
13 amino acids
C96H122N24O14
Standard
Sequence
ILPWGWPWWPWRR
Physicochemical Analysis
1836.15 Da
12.00
1.76
1.56
0.1354
-0.80
0.31
0.17
77.79
60.00
0.3846
27500.00
27500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
588.90
3.60
22.0
16.0
44.0
134.0
13.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016152 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 9017656 B2 Evidence URLhttps://patents.google.com/patent/US9017656B2/en PatentUS 9017656 B2
RECORD: Rec_0154098 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
49 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperSynthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin. | Krajewski K, Marchand C, Long YQ, Pommier Y, Roller PP. | Bioorg Med Chem Lett. 2004 Nov 15;14(22):5595-8. | DOI:10.1016/j.bmcl.2004.08.061 | PMID:15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0155011 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of strand transfer catalyzed by integrase
19 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperSynthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin. | Krajewski K, Marchand C, Long YQ, Pommier Y, Roller PP. | Bioorg Med Chem Lett. 2004 Nov 15;14(22):5595-8. | DOI:10.1016/j.bmcl.2004.08.061 | PMID:15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/