Peptide Database

Peptide NameOrexin-A

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling

Neurological / Signaling ▸ Sleep regulation

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell-cell communication

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC152H249N47O45S4

DescriptionStandard

        QPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL
    

Molecular Weight3583.15 Da

Isoelectric Point (pI)7.90

Net Charge (pH 7.0)0.90

Net Charge (pH 7.4) 0.53

Charge Density (pH 7.0) 0.0272

GRAVY Index-0.06

Hydrophobic Moment 0.50

Boman Index0.03

Instability Index27.49

Aliphatic Index 91.82

Aromaticity 0.0303

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1740.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1468.91

LogP -16.04

H-bond Donors 54.0

H-bond Acceptors 52.0

Rotatable Bonds 115.0

Heavy Atoms 248.0

Ring Count 5.0

Amide Bonds 35.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0418759 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyOrexin

Tax ID9823

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

C-TermAmidation

Disulfide6-12; 7-14

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Receptor modulation Sleep regulation Wake regulation Feeding regulator

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

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