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MYP_128374
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Basic Information
Orexin-A
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Neurological / Signaling ▸ Sleep regulation
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
33 amino acids
C152H249N47O45S4
Standard
Sequence
QPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL
Physicochemical Analysis
3583.15 Da
7.90
0.90
0.53
0.0272
-0.06
0.50
0.03
27.49
91.82
0.0303
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1468.91
-16.04
54.0
52.0
115.0
248.0
5.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0211274 VERIFIED: YES
Provenance & Taxonomy
Canis familiaris [Animal]
Orexin
9615
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
Bio-Activity Profile
Neuropeptide Neuromodulator
PMID9491897 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9491897/
RECORD: Rec_0267450 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Orexin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Amidation
6-12; 7-14
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Receptor modulation Sleep regulation Wake regulation Feeding regulator
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
RECORD: Rec_0278202 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0373610 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Orexin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
Bio-Activity Profile
Neuropeptide Neuromodulator
PMID9491897 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9491897/
RECORD: Rec_0415761 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
orexin family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
6-12; 7-14
Bio-Activity Profile
Neuropeptide orexin family Neuropeptide signaling
PaperPDB 1R02 structural record; NMR; chain A; residues 1-33
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