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MYP_128374
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Basic Information
Orexin-A
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Neurological / Signaling ▸ Sleep regulation
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
33 amino acids
C152H249N47O45S4
Standard
Sequence
QPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL
Physicochemical Analysis
3583.15 Da
7.90
0.90
0.53
0.0272
-0.06
0.50
0.03
27.49
91.82
0.0303
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1468.91
-16.04
54.0
52.0
115.0
248.0
5.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0117866 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Orexin
9913
Structure & Mods
disulfide-constrained peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Amidation
6-12; 7-14
Bio-Activity Profile
Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Sleep regulation Wake regulation Feeding regulator
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Orexin-A (Bos taurus): PMID 9491897 PMID9491897 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9491897/
RECORD: Rec_0142902 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Orexin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
Bio-Activity Profile
Neuropeptide Neuromodulator
PMID9491897 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9491897/
RECORD: Rec_0146705 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 45.5%, E 0.0%, T 33.3%, C 21.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0149737 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Orexin
10090
Structure & Mods
disulfide-constrained peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Amidation
6-12; 7-14
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Receptor modulation Sleep regulation Wake regulation Feeding regulator
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
RECORD: Rec_0171973 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Orexin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
Bio-Activity Profile
Neuropeptide Neuromodulator
PMID9491897 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9491897/
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