Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length393 amino acids

Chemical FormulaC2009H3161N553O560S16

DescriptionStandard

        MMARPYCVVVALLLLAMVSGFGEGASNPGFVARITRKGLEYGRRFGVAILKKELSTIKLPDFSGSFKVGWIKSVSYDFYRLKIHRFELRNSDLRLRPRQGVTASLSNNYVFVSGNWKVKKAFVTLDGTFDVSVDGISISVSLNLGKDHSGRPTASVAHCRSSIGHISADISGRLSWILNLFHERIENNFKNILEQKVDKRMSSFVICEMVRKSTTSHLEPYLRTLPVILMIDQVAGIDYSLVGAPQVTSQVLDTPFKGEFFGRNWHSPAPFDAPTIRLTEKHDHMVYFAVSEYVFNTASRVYHQAGRMNFTIQNKHIPMDSPIRLHTSSFRTIIPRLARLNPNMELELETSPETAYLLEQWVKIKVIKLIFMYKNSHHCLTPCGIKTQDLDSD
    

Molecular Weight44534.00 Da

Isoelectric Point (pI)9.54

Net Charge (pH 7.0)14.71

Net Charge (pH 7.4) 13.62

Charge Density (pH 7.0) 0.0374

GRAVY Index-0.11

Hydrophobic Moment 0.83

Boman Index0.04

Instability Index30.91

Aliphatic Index 91.48

Aromaticity 0.0992

Extinction Coeff. Reduced 45380.00

Extinction Coeff. Oxidized 45630.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0054958 VERIFIED: NO

Provenance & Taxonomy

OrganismUrsus maritimus [Animal]

FamilyBPI

Tax ID29073

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence