Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length651 amino acids

Chemical FormulaC3235H5053N879O903S25

DescriptionStandard

        MKFLGGGIWMRAQRGVWGCLGNDAQSQKSHPITHAHHTYPTHITHTPPTPPPPSPYISHTQHHHTHCYTHTPYMPAKHAPPPHTHTQTCVHTHMSHAHLLPLTPQLPGSTLGPNHGRQQPSPSPAPTQFPSSFLHPTGLHFPSQLLYRSLAPLQGLKALAALEDEDMARHPDNALRWATLLVLAILGTAAVVTTTNPGVVARITQKGLDYACQQGVAVLQKELEKIKIPTFSGSFKVKHLGKGHYSFYSMVIRGFQLPSSQIKLVPNKGLDLSIRNANIKISGKWKARKNFIKTSGNFDLSVESISISAGLNMSFDPTSGHLTIICSSCNNYIDSVRVHISGGRLGWLIQLFHKKIESAIRKTMNNKICQVVSSSVSSRLQSYLKTLPVTYKIDRIAGISYSLVAPPTATADNLDGHLKGEFFSLAHPRSPPFTPPAMALPPDHDHMVYLGISDYFFNTAGLVYQEAGALNMTITDDMIPKKSKFRLTTDFLGTLIPQVAEMFPNMTVQFNVWASSPPHLTMRPAGLIFTPTLDTQAFAVLPNSSLAPLFVLGLSTNLSMEVSARPDRLVGQLSLDKLLLELKHSDVGSFSVAVLQSIMNYVVPTAVLPKVNERLQEGFPLPMPKNVQLFNLVLQTHQDFLLFGADVHYSG
    

Molecular Weight71508.70 Da

Isoelectric Point (pI)9.41

Net Charge (pH 7.0)18.58

Net Charge (pH 7.4) 16.33

Charge Density (pH 7.0) 0.0285

GRAVY Index-0.10

Hydrophobic Moment 0.75

Boman Index0.11

Instability Index42.44

Aliphatic Index 88.23

Aromaticity 0.0799

Extinction Coeff. Reduced 58330.00

Extinction Coeff. Oxidized 58705.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0233249 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris (Dog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria