Peptide Database

Peptide NameInsulin-like growth factor I

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length70 amino acids

Chemical FormulaC336H522N96O102S7

DescriptionStandard

        GPETLCGAELVDTLQFVCGDRGFYFSKPTGYGPSSRRSHNRGIVDECCFQSCELRRLEMYCAPVKPGKTP
    

Molecular Weight7762.78 Da

Isoelectric Point (pI)7.77

Net Charge (pH 7.0)0.80

Net Charge (pH 7.4) 0.44

Charge Density (pH 7.0) 0.0114

GRAVY Index-0.46

Hydrophobic Moment 0.47

Boman Index-0.08

Instability Index62.71

Aliphatic Index 52.86

Aromaticity 0.1000

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3167.05

LogP -35.40

H-bond Donors 116.0

H-bond Acceptors 111.0

Rotatable Bonds 248.0

Heavy Atoms 541.0

Ring Count 14.0

Amide Bonds 72.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0313983 VERIFIED: YES

Provenance & Taxonomy

OrganismCyprinus carpio [Animal]

FamilyInsulin-like growth factor

Tax ID7962

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-48; 18-61; 47-52

Bio-Activity Profile

Function

Hormone Endocrine Growth regulation Development regulation

Half-LifeMammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0348032 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0426943 VERIFIED: NO

Provenance & Taxonomy

OrganismCyprinus carpio [Animal]

FamilyInsulin

Tax ID7962

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Metabolic