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MYP_128226
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Basic Information
Mersacidin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
20 amino acids
C81H132N20O28S4
Standard
Sequence
CTFTLPGGGGVCTLTSECIC
Physicochemical Analysis
1962.29 Da
4.05
-1.28
-1.54
-0.0638
0.94
0.21
0.39
108.01
73.00
0.0500
0.00
250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
745.88
-10.22
30.0
31.0
59.0
133.0
2.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0274258 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0288303 VERIFIED: YES
Provenance & Taxonomy
Bacillus sp. strain HIL Y-85 54728 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Micrococcus lutues ATCC 9341
0.195 μg/mL
MIC
PMID1500347 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1500347/
RECORD: Rec_0323669 VERIFIED: YES
Provenance & Taxonomy
Bacillus sp [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
The smallest lantibiotic known to date. Chemical modification: There are 9 post-translational modifications leading to four ring structures, residues 1-2,4-12, 13-18, and 15-20. Residues 2,4,13, and 15 are Abu. The ring structure confers chemical stability and proteolysis resistance of the peptide
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus 20424
3.12 μg/mL
MIC
PaperMersacidin, a new antibiotic from Bacillus. Fermentation, isolation, purification and chemical characterization.
RECORD: Rec_0338523 VERIFIED: YES
Provenance & Taxonomy
Bacillus sp. HIL-Y85 [Bacterium],54728 [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Vancomycin-resistant Enterococcus
PaperPubMed PMID: 7737474 | PubMed PMID: 9119018 | PubMed PMID: 10831439 | PubMed PMID: 10818347 PMID7737474;9119018;10831439;10818347 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7737474/
RECORD: Rec_0377442 VERIFIED: YES
Provenance & Taxonomy
Bacillus sp [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
The smallest lantibiotic known to date. Chemical modification: There are 9 post-translational modifications leading to four ring structures, residues 1-2,4-12, 13-18, and 15-20. Residues 2,4,13, and 15 are Abu. The ring structure confers chemical stability and proteolysis resistance of the peptide
Bio-Activity Profile
Antimicrobial
Micrococcus luteus ATCC 9341
0.195 μg/mL
MIC
PaperMersacidin, a new antibiotic from Bacillus. Fermentation, isolation, purification and chemical characterization.
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