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MYP_128203
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Basic Information
WQ-IDL(628-656)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
29 amino acids
C167H263N41O53
Standard
Sequence
WEEWDKKIEEYTKKIEELIKKSQNQQIDL
Physicochemical Analysis
3693.12 Da
4.86
-2.23
-2.45
-0.0768
-1.53
0.69
-0.32
64.54
80.69
0.1034
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1597.27
-10.40
53.0
51.0
134.0
261.0
5.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0013947 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 clinical isolates(8 clinical isolates):inhibition of virus infection in MT-2 cells
0.002-0.0907 μM
IC50
PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
RECORD: Rec_0037294 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 PsV
PMID27795416;31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
RECORD: Rec_0057676 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 9489
PMID27795416;31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
RECORD: Rec_0077386 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
PMID27795416;31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
RECORD: Rec_0081266 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 T20-resistant strains (5 strains) | MT-2 cells
0.0016-0.022 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperCreating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors. | Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L. | J Virol. 2016 Dec 16;91(1):e01445-16. | DOI:10.1128/JVI.01445-16 | PMID:27795416 PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
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