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MYP_128187
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Basic Information
Viphi F
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
31 amino acids
C134H218N34O42S6
Standard
Sequence
GSIPCGESCVFIPCISAIIGCSCSSKVCYKN
Physicochemical Analysis
3169.76 Da
7.77
0.70
0.40
0.0226
0.81
0.32
0.29
28.81
84.84
0.0645
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1192.78
-14.87
47.0
49.0
100.0
216.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0119757 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0124147 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID21723349 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21723349/
RECORD: Rec_0150758 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Cyclotide
39648
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
Human gastric cancer BGC-823
2.91±0.06 μM
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola philippica | PubMed PMID 25815330 PMID25815330 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25815330/
RECORD: Rec_0235712 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Cyclotide
39648
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
Human foreskin fibroblasts HFF-1
1.76±0.12 μM
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola philippica | PubMed PMID 25815330 PMID25815330 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25815330/
RECORD: Rec_0248688 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Cyclotide
39648
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
Human skin melanoma MM96L
1.03±0.03 μM
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola philippica | PubMed PMID 25815330 PMID25815330 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25815330/
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