Peptide Database

Peptide NameSLAY-screened peptide P1747

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC104H143N23O37

DescriptionStandard

        SHTPPLDNSISFDSDTTYYF
    

Molecular Weight2307.38 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-3.45

Net Charge (pH 7.4) -3.71

Charge Density (pH 7.0) -0.1726

GRAVY Index-0.72

Hydrophobic Moment 0.25

Boman Index0.04

Instability Index29.82

Aliphatic Index 39.00

Aromaticity 0.2000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 964.38

LogP -11.53

H-bond Donors 33.0

H-bond Acceptors 35.0

Rotatable Bonds 66.0

Heavy Atoms 164.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0400572 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/