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MYP_128145
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
16 amino acids
C78H133N19O22
Standard
Sequence
AVDLAKIANKVLSSLF
Physicochemical Analysis
1689.00 Da
8.63
0.80
0.60
0.0497
1.01
0.63
0.30
16.21
152.50
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
672.71
-4.94
23.0
23.0
57.0
119.0
1.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0172131 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
C-terminal amidation
Bio-Activity Profile
Antimicrobial
Escherichia coli
37.5 μM
MIC
PaperMolecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi.
RECORD: Rec_0194078 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
C-terminal amidation
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
>150 μM
MIC
PaperMolecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi.
RECORD: Rec_0205711 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic
posseses hemolytc activity
250 μM
LD50
RECORD: Rec_0255903 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0257493 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic Anti-Gram-negative
Gram-negative bacteria
37.5 μM
MIC
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