MYP_128121
Tryglysin A
Antimicrobial
Standard
7 amino acids
C37H54N12O10
Standard
VNSWGKH
826.90 Da
8.73
0.82
0.56
0.1172
-1.21
0.56
-0.07
-18.37
41.43
0.1429
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
371.73
-3.72
13.0
12.0
25.0
59.0
3.0
7.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0063333
VERIFIED: YES
Provenance & Taxonomy
Streptococcus ferus [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
APD analysis reveals this sequence is most similar (38.5%) to Panurgine 1. Chemical modification: The side chain of alpha and delta carbons of K6 are fused with the six membered ring of W4 (by forming two C-C bonds) into one additional six-membered aliphatic ring. The peptide Tryglysin was named after the tryptophan, glycine, and lysine amino acids that are involved in the macrocycle. This macrocyclic modification is unprecedented, and falls into two classes of universal classification since the two C-C bond involving both backbone and sidechain of lysine. Culture expression: This peptide expression commences in early stationary phase, peaking at late exponential phase at ~1 uM bulk concentration. It retains a relatively high concentration at stationary phase
Bio-Activity Profile
Antimicrobial